Agilent 1260 Infinity II LC System
The Agilent 1260 Infinity II LC System is a high-performance liquid chromatography (HPLC) platform designed for laboratories that demand precision, reliability, and scalability. Engineered to handle a wide range of analytical challenges, this modular system combines cutting-edge technology with user-friendly operation, making it ideal for both routine analysis and complex research applications.
Featuring robust and flexible modules—including quaternary or binary pumps, high-precision autosamplers, thermostatted column compartments, and advanced detectors—the 1260 Infinity II ensures accurate and reproducible results across a variety of sample types. Its advanced software integration provides seamless control, method development, and data analysis, streamlining workflows and maximizing laboratory efficiency.
The system supports high-throughput analyses without compromising sensitivity, offering exceptional performance for applications in pharmaceuticals, life sciences, food and beverage testing, environmental monitoring, and chemical research. Built for longevity and low maintenance, the Agilent 1260 Infinity II LC System combines reliability with superior analytical capability, delivering consistent results and confidence in every experiment.
Key Features
Modular Design – Fully configurable with quaternary or binary pumps, autosamplers, column compartments, and detectors to fit your specific workflow.
High Precision & Reproducibility – Delivers consistent retention times and peak areas, ideal for routine analysis and complex research.
Advanced Autosampler – Supports large sample capacity, automated dilution, and precise injection for high-throughput laboratories.
Temperature-Controlled Column Compartment – Ensures reproducible separations by maintaining consistent column temperatures.
Flexible Detection Options – Compatible with UV/Vis, diode array (DAD), fluorescence, and refractive index detectors for versatile applications.
User-Friendly Software Integration – Controlled via Agilent OpenLab CDS or ChemStation for seamless method development, instrument control, and data analysis.
Wide Range of Applications – Suitable for pharmaceuticals, biopharmaceuticals, food and beverage testing, environmental analysis, and chemical research.
Low Maintenance & Reliability – Designed for extended operational life with reduced downtime and minimal routine maintenance.
High Sensitivity & Resolution – Optimized fluidics and detectors provide superior peak resolution and signal-to-noise performance.
Scalable Workflow – Easily upgraded with additional modules to meet growing laboratory demands.
Technical Specifications
Pump (Quaternary / Binary)
Flow Rate Range: 0.001 – 5 mL/min (adjustable in 0.001 mL/min increments)
Recommended Operational Range: 0.05 – 5 mL/min
Flow Precision: ≤ 0.07 % RSD or ≤ 0.02 min SD
Flow Accuracy: ± 1 % or 10 µL/min
Maximum Operating Pressure: Up to 60 MPa (600 bar / 8702 psi)
Pressure Pulsation: < 2 % amplitude (typically <1.3 %)
Solvent Composition Precision: < 0.15 % RSD
Solvent Composition Accuracy: ± 0.35 % absolute
Autosampler
Injection Volume: 0.1 – 90 µL (in 0.1 µL steps)
Injection Precision: < 0.15 % RSD or SD < 10 nL
Maximum Pressure: Up to 800 bar
Sample Viscosity Range: 0.2 – 5 cP
Sample Capacity: Configurable (multiple drawer options available)
Fast Injection Cycle: < 10 s with multi-directional washes and seat backflush to minimize carryover (< 0.003 %)
Column Compartment (Multicolumn Thermostat)
Temperature Range: 4 °C to 110 °C (down to ~20 °C below ambient)
Temperature Stability: ± 0.03 °C
Temperature Accuracy: ± 0.5 °C
Temperature Precision: 0.05 °C
Turnaround Time:
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Ambient → 40 °C: ~5 min
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40 °C → 20 °C: ~10 min
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25 °C → 100 °C: < 30 min
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Detector Options
Detection Type: 1024‑element photodiode array
Wavelength Range: 190 – 950 nm
Data Rate: Up to 120 Hz
Short-Term Noise: < ± 0.7 × 10⁻⁵ AU (ASTM, at 254 nm & 750 nm)
Drift (254 nm): < 0.9 × 10⁻³ AU/h
Linear Absorbance Range: > 2 AU at 265 nm
Wavelength Accuracy: ± 1 nm
General & System Features
Maximum Operating Pressure: Up to 600 bar (UHPLC-ready in some configurations)
Modular Design: Configurable with pumps, detectors, thermostats, and samplers
Software Control: Agilent OpenLab CDS or compatible platforms for method setup, control, and data processing
Carryover Minimization: Multi-wash and backflush capabilities for reduced sample contamination

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